Endocrine Abstracts

Obesity belongs to the five most important health burdens in modern societies and reaches with ~20% prevalence in Germany epidemic proportions. Obesity significantly increases the risk of developing metabolic (e.g. type 2 diabetes), cardiovascular, orthopaedic, psychologic, and other disorders. Despite the well established epidemiologic relationship between obesity and these co-morbidities, there is a subgroup of metabolically healthy obese patients, which seems to be protecte...

Tumor necrosis factor alpha-induced adipose-related protein (TIARP)/six-transmembrane protein of prostate 2 (STAMP2) has been characterized as an adipocyte-expressed protein which might play a crucial role in metabolic homeostasis and inflammatory pathways. In the current study, the impact of insulin resistance-inducing and proinflammatory interleukin (IL)-1ß on TIARP/STAMP2 gene expression was determined by quantitative real-time reverse transcription-polymerase chain re...